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KMID : 0387420200310030149
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Korean Society of Oriental Neuropsychiatry
2020 Volume.31 No. 3 p.149 ~ p.156
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An Experimental Study on the Effect of Chengsimyeonjatanggagam Extracts on the ADHD Animal Model
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Oh Young-Je
Liu Quan Feng
Kim Man-Gi
Hong Min-Ho
Kim Geun-Woo
Koo Byung-Soo
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Abstract
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Objectives: The purpose of this study was to experimentally assess the effects of Chengsimyeonjatanggagam extracts in the animal model regarding ADHD related symptoms and indicators.
Methods: The experimental group was classified into the normal group (WKY rat) in 7, the control group (SHR rat) in 7, the low-concentration group of herbal medicines (SHR rat) in 7, and the highconcentration group of herbal medicines (SHR rat) in 7 by random sampling. The open field test was conducted three times on the 7th, 14th, and 21st days during the oral medication. After that, Y-maze test, intestinal permeability verification (L/M ratio), and Western blotting (CDK expression in the cerebral cortex) were performed in sequence.
Results: The Chengsimyeonjatang-gagam extracts reduced the activity distance in the SHR rat at 21 days in the low and high concentration groups by the open field test. It also reduced the cross-action rate in the low and high concentration groups by the Y-maze test. And the low concentration group showed 52.3% decrease in the L/M ratio compared to the SHR group. Finally, the CDK5 protein significantly increased in the low and high concentration groups.
Conclusions: This study suggests that the Chengsimyeonjatang-gagam extracts have potential to be used for the treatment of ADHD.
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KEYWORD
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Herbal medicine, ADHD, Chengsimyeonjatang, Chengsimyeonjatang-gagam, L/M ratio, CDK5
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